Gobal optimization of hybrid kinetic/FBA models via outer-approximation
نویسندگان
چکیده
Flux balance analysis (FBA) is a linear programming-based framework widely used to predict the behavior, in terms of the resulting flux distribution, of cellular organisms in different media. FBA models are constructed using only stoichiometric information, and for this reason they sometimes fail in predicting fluxes precisely. In this work, we formally define the concept of hybrid FBA/kinetic models, in which kinetic information of key processes is used to tighten the search space of standalone FBA formulations,
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عنوان ژورنال:
- Computers & Chemical Engineering
دوره 72 شماره
صفحات -
تاریخ انتشار 2015